TruOrigin
Prove the Indigeneity of Your Microbial Products—Fast, Accurate, and APHIS-Ready
A streamlined genomic validation service to support USDA APHIS permitting without costly soil sampling.
Problem:
Companies must demonstrate species indigeneity to obtain USDA APHIS permitting before product testing
Traditional Approach:
Soil sampling, microbial isolation, sequencing. Costly, slow, logistically complex
EarthOptics Solution:
Leader in biological analysis and strain detection. Fast, cost-effective, APHIS-ready
TruOrigin™ Indigeneity Verification Service
EarthOptics TruOrigin™ enables biological product companies to prove the native presence of bacterial or fungal species across the Midwest. We compare customer-provided genomes against our biological analysis to identify county-level distribution.
Unmatched Scale & Precision
Scale & Coverage
- 95,000+ environmental samples analyzed across 10,500+ field sites
- Building the world's largest soil microbiome database
- Geographic distribution mapping across entire regions
- Abundance profiling against 3,500+ tracked soil bacteria
Superior Specificity
- >99.9% specificity using competitive mapping approach
- False positive rate: <0.04% after filtering
- Whole-genome indices distinguish closely related species
- Validated against synthetic reads from related species
Custom Strain Detection
Deploy our genomic analysis platform to detect and quantify your proprietary microbial strains under field or manufacturing conditions.
Environmental Monitoring Services
Leverage our established sampling network to monitor target organisms across geographic regions.
Licensing and Integration
License our competitive algorithms and validation frameworks for integration into your existing laboratory workflows.
USDA APHIS requires proof that species are indigenous to intended deployment regions. Without this evidence, products cannot be tested, sold or deployed.
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Faster path to USDA APHIS approval
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Broader U.S. species distribution insight
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Reduced cost and operational burden
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Intelligence for field testing and commercialization
Rigorous Scientific Validation
Key technical details:
- Competitive mapping using whole-genome indices
- Species-level detection with ANI-based clustering (95% threshold)
- Conservative filtering cascade (mapQ, alignment length, percent identity)
- False positive validation using synthetic reads
- Subsampling and abundance-based validation
Breakthrough Applications for Biotech
Five application areas:
- Drug discovery programs requiring specific microbial strains
- Agricultural biotech development and strain optimization
- Environmental monitoring for pharmaceutical manufacturing
- Bioremediation and industrial biotechnology applications
- Quality control and contamination detection in bioprocessing